Head of Center for Clinical Research
University Freiburg Medical Center
Scientific Director Department of Urology, Director Center for Clinical Research Speaker. Prof. Schüles working group is specifically focused on finding out whether this is due to the removal of methyl groups from the chromatin or more likely due to the lack of demethylation. The group aims to obtain detailed information about the role of LSD1 by specifically looking at the dysregulation of it. As overexpression of LSD1 leads to the development of prostate and lung tumours in old mice the researchers will focus on finding out why this happens.
Basic epigenetic mechanisms in cellular assays and explorative mouse models Validation of epigenetic control in animal models of disease Transfer of epigenetic principles to clinical applications