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2nd International Congress on Epigenetics & Chromatin, will be organized around the theme “Revolutionary Strategies in Diagnosis and Treatment of Cancer and Genetic Disorders”
Epigenetics 2017 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in Epigenetics 2017
Submit your abstract to any of the mentioned tracks.
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Research in computational epigenetics comprises the development and application of bioinformatics methods for solving epigenetic questions, as well as computational data analysis and theoretical modeling in the context of epigenetics. This includes modelling of the effects of histone and DNA CpG island methylation.
- Track 1-1Epigenetics inhibitors and emerging targets
- Track 1-2Higher order chromatin
- Track 1-3DNA methylation
- Track 1-4Replication/ epigenetic memory
- Track 1-5Transcription/ euchromatin
- Track 1-6Gene control by metabolism
- Track 1-7Histone variants/ exchange
Epigenetic aberration is ubiquitous in cancer, and therefore has recently been added as a hallmark of cancer. As such, much effort has been recently devoted to identifying components of the epigenetic machinery critical to driving the oncogenic process which may represent novel therapeutic targets. Due to these efforts, great strides have been made in this regard, with a number of promising epigenetically targeted compounds now in various stages of pre-clinical and clinical development.
- Track 2-1Novel epigenetics targets in cancer
- Track 2-2Histone variants and histone modifications
- Track 2-3Non-coding RNA
- Track 2-4Cancer stem cells
- Track 2-5Epigenetic tools and technologies
- Track 2-6Epigenetics mechanism of drug resistance
- Track 2-7Genetic and epigenetic aspects of breast cancer progression
- Track 2-8Breast cancer risk and prevention
Clinical epigenetics is the application of molecular biology techniques detecting alterations in DNA methylation or histone modification to diagnose or study disorders characterized by heritable defects in the expression of a gene or genome. Applications include Rett syndrome, disorders of imprinting, uniparental inheritance of chromosomes and chromosome segments, and somatic epigenetic anomalies in cancers.
- Track 3-1Epigenetics of super-centenarians
Our understanding of epigenetic mechanisms and our appreciation of their impact on all biological processes have rapidly expanded in the past decade. Epigenetic mechanisms encode information that adds functional layers to the genetic content of the genome, affecting gene expression during developmental programs as well as contributing to disease states in adult organisms. Heritable epigenetic encoding can occur in response to environmental changes, creating phenotypic variation with wide ranges of stability.
- Track 4-1RNA-dependent modes of epigenetic regulation
- Track 4-2Cardiovascular Epigenetics
- Track 4-3Cardiovascular Epigenetics
- Track 4-4Epigenetics and disease
- Track 4-5Targeted epigenetic modification
- Track 4-6Inheritance of epigenetic states
- Track 4-7Dynamics of epigenetic states
- Track 4-8Epigenetics and nuclear organization
- Track 4-9Epigenetic control of genome integrity
- Track 4-10Epigenetic control of development and dosage
- Track 4-11New epigenetic phenomena
- Track 4-12Epigenetics and ethics
Epigenetic changes potentially useful as tumor markers are now under clinical trials, and useful markers will be selected. Risk prediction and cancer prevention are also promising areas of epigenetics. A high efficacy of demethylating agents was reported mainly in hematological malignancies based on new protocols (lower dose and/or longer exposure), and their use is now being tried for solid tumors.
- Track 5-1Cancer
- Track 5-2Mental retardation disorders
- Track 5-3Immunity & related disorders
- Track 5-4Neuropsychiatric disorders
- Track 5-5Pediatric syndromes
- Track 5-6Forensic Epigenetics
- Track 5-7Epigenetic approaches to psychiatric disorders
Epigenetics refers to heritable changes in gene expression that occur without alteration in DNA sequence. These changes may be induced spontaneously, induced by environmental factors or as a consequence of specific mutations. There are two primary and interconnected epigenetic mechanisms: DNA methylation and covalent modification of histones.
- Track 7-1Single-cell epigenetics
- Track 7-2Epigenetic gene regulation
- Track 7-3Epigenetic gene regulation
- Track 7-4Stem cells and regenerative medicine
- Track 7-5Behavioral epigenetics
- Track 7-6Epigenetic therapy
- Track 7-7Toxicoepigenetics
- Track 7-8Transgenerational inheritance
- Track 7-9Developmental epigenetics
- Track 7-10Epigenetics and metabolism
- Track 7-11Transcriptional regulation and epigenetics
- Track 7-12Chromatin architecture
- Track 7-13Epigenetics analysis
The term epigenetics refers to heritable changes in gene expression (active versus inactive genes) that does not involve changes to the underlying DNA sequence; a change in phenotype without a change in genotype.
This session is to evaluate the recent scientific knowledge in the field of epigenetics and environmental origins of cancer, to determine future research needs in this area, and to assess the implications of such studies in cancer causation and prevention. We will also discuss how advances in epigenomics and the emergence of powerful technologies as well as state-of-the-art in vitro approaches may help understand mechanisms underlying epigenome deregulation by the environment and identifying epigenetic biomarkers.
- Track 9-1Epigenetic effects of air pollutant exposure
- Track 9-2Chromatin dynamics
- Track 9-3Signalling to chromatin
- Track 9-4Nuclear architecture and dynamics
- Track 9-5Developmental epigenetics
- Track 9-6Epigenetics and human diseases
- Track 9-7Genome stability
- Track 9-8Ecological epigenetics
In the nutritional field, epigenetics is exceptionally important, because nutrients and bioactive food components can modify epigenetic phenomena and alter the expression of genes at the transcriptional level. Folate, vitamin B-12, methionine, choline, and betaine can affect DNA methylation and histone methylation through altering 1-carbon metabolism.
Epigenetic inheritance is an unconventional finding. It goes against the idea that inheritance happens only through the DNA code that passes from parent to offspring. It means that a parent's experiences, in the form of epigenetic tags, can be passed down to future generations.
Histones and DNA are chemically modified with epigenetic markers that influence chromatin structure by altering the electrostatic nature of the chromatin or by altering the affinity of chromatin-binding proteins. DNA can be modified by methylation of cytosine bases
This term is used to refer to heritable alterations that are not due to changes in DNA sequence. Rather, epigenetic modifications, or “tags,” such as DNA methylation and histone modification, alter DNA accessibility and chromatin structure, thereby regulating patterns of gene expression.
DNA methylation is an epigenetic mechanism that occurs by the addition of a methyl (CH3) group to DNA, thereby often modifying the function of the genes.
Epigenetic gene silencing refers to nonmutational gene inactivation that can be faithfully propagated from precursor cells to clones of daughter cells. The addition of methyl groups to cytosine residues in CpG dinucleotides in DNA is a biochemical modification that meets this requirement.
Epigenetic therapy is the use of drugs or other epigenome-influencing techniques to treat medical conditions. Many diseases, including cancer, heart disease, diabetes, and mental illnesses are influenced by epigenetic mechanisms, and epigenetic therapy offers a potential way to influence those pathways directly.
Epigenomics is the study of the complete set of epigenetic modifications on the genetic material of a cell, known as the epigenome. The field is analogous to genomics and proteomics, which are the study of the genome and proteome of a cell. Epigenetic modifications are reversible modifications on a cell’s DNA or histones that affect gene expression without altering the DNA sequence.
- Track 19-1Genomics
- Track 19-2Ciliate molecular biology
- Track 19-3Transgenerational inheritance
- Track 19-4Vasculitis and autoimmune disease
- Track 19-5Legal and Ethical Implications of Epigenomics
A genetic disorder is a genetic problem caused by one or more abnormalities in the genome, especially a condition that is present from birth (congenital). Most genetic disorders are quite rare and affect one person in every several thousands or millions. Genetic disorders may be hereditary, passed down from the parents' genes. In other genetic disorders, defects may be caused by new mutations or changes to the DNA. In such cases, the defect will only be passed down if it occurs in the germ line.
- Track 20-1Human genetics
- Track 20-2Genetic testing
- Track 20-3Molecular genetics
- Track 20-4Evolutionary and population genetics
- Track 20-5Evolutionary genetics
- Track 20-6Clinical genetics
Immunogenetics or immungenetics is the branch of medical research that explores the relationship between the immune system and genetics. Autoimmune diseases, such as type 1 diabetes, are complex genetic traits which result from defects in the immune system.
- Track 21-1Autoimmune diseases
- Track 21-2Platelet immunology
- Track 21-3Granulocyte immunology
- Track 21-4Multiple sclerosis
- Track 21-5Diabetes type I
- Track 21-6Rheumatoid arthritis
- Track 21-7Crohn’s disease
- Track 21-8Vasculitis and autoimmune disease
Epigenetic modifications such as methylation of CpGs (a dinucleotide composed of a 2'-deoxycytosine and a 2' deoxyguanosine) and histone tail modifications allow activation or repression of certain genes within a cell, in order to create cell memory either in favor of using a gene or not using a gene. These modifications can either originate from the parental DNA, or can be added to the gene by various proteins and can contribute to differentiation.
- Track 22-1Pharmacogenetics
- Track 22-2Cancer and neurodevelopment
- Track 22-3Statistical genetics
- Track 22-4Clinical epigenetics and biomarkers
- Track 22-5Epigenetics of Neurodegenerative Diseases
Pharmacogenomics is the study of the role of the genome in drug response. Its name (pharmaco- + genomics) reflects its combining of pharmacology and genomics. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with pharmacokinetics and pharmacodynamics (drug absorption, distribution, metabolism, and elimination), as well as drug receptor target effects.
- Track 24-1Translational pharmacogenomics
- Track 24-2Pharmacogenitics & Individualized therapy
- Track 24-3Cancer pharmacogenomics
- Track 24-4Pharmacogenomics
- Track 24-5Molecular diagnostics
- Track 24-6Molecular-targeted interventions including gene therapy
- Track 24-7Biological and small molecule therapeutics
- Track 24-8Biomarker translation and testing
- Track 24-9Toxicogenomics
- Track 24-10Nutrigenomics
- Track 24-11Applications of NGS to pharmacogenomics
- Track 24-12Pharmacogenomics in clinical therapeutics
The risk of reproductive problems, such as infertility, miscarriage, and ongoing pregnancy complications, increases as women age. While chromosomal errors play a significant role, environmental exposures are increasingly appreciated to play a role in modifying gene expression through epigenetic regulation during development, and may also affect fetal growth and later fertility.
- Track 25-1Epigenetics in reproductive medicine
- Track 25-2Epigenetic modification and human reproduction
Cancer epigenetics research is now entering an exciting phase of translational epigenetics whereby novel epigenome therapeutics is being developed for application in clinical settings. Epigenetics refers to all heritable and potentially reversible changes in gene or genome functioning that occurs without altering the nucleotide sequence of the DNA. A range of different epigenetic "marks" can activate or repress gene expression.
- Track 26-1Cancer genetics
- Track 26-2Drug discovery
- Track 26-3Human physiology
- Track 26-4Cytogenetics
- Track 26-5Transplantation